The social and economic cost of COVID-19 has revealed that prevention strategies are potentially very cost effective by comparison to coping with a pandemic. The actions by Public Administrations and businesses need new approaches in order to benefit in health and quality of life. As a consequence, the concept of Future Cities and Industries as human-centered realities that balance economic and technological advancement to solve society’s problems is urgent. It represents a new vision for a resilient society where humans, nature and technology create a resilient and sustainable balance enhanced by data. This new digital transformation results in new resilient and sustainable environments permeated by a sustainable economy and the creation of products and services with low environmental impact and high social impact.